Short Course Description
Molecular Signaling
*How the cell sense the environment
*Receptors and Ligands that mediate signaling
*Molecular structure of Receptors and Ligands
*Receptors with enzymatic activities
*Growth Factors: NGF and Neurotrophic factors: structure and function.
*Receptor Tyrosine Kinases: Nomenclature, structure and function, ligand
binding, dimerization, signaling pathways, involvement in cancer.
* Non receptor tyrosine kinases
*G-protein coupled receptors: structure, functions and signaling pathways.
*Small G-proteins (Ras, Rho)
*Signaling pathways: PLC, PI3K, MapK
*regulation of the cytoskeleton organization
*Regulation of cell death, survival and development by autophagy
* Cell death ( apoptosis) induction of apoptosis by death receptors.
*Bcl-2 family of proteins.
*Caspases
The grade will be determined by a Seminar paper which will be also presented as a lecture to the whole class (the topic will be determined in agreement with the lecturer).
Full syllabus will be available to registered students only
